Effects of Lactobacillus rhamnosus Strain GG in Pediatric Obesity-related Liver Disease

@article{Vajro2011EffectsOL,
  title={Effects of Lactobacillus rhamnosus Strain GG in Pediatric Obesity-related Liver Disease},
  author={Pietro Vajro and Claudia Mandato and Maria Rosaria Licenziati and Adriana Franzese and Dino Franco Vitale and Selvaggia Lenta and Maria Caropreso and Gianfranco Vallone and Rosaria Meli},
  journal={Journal of Pediatric Gastroenterology and Nutrition},
  year={2011},
  volume={52},
  pages={740–743}
}
  • P. Vajro, C. Mandato, +6 authors R. Meli
  • Published 1 June 2011
  • Medicine, Biology
  • Journal of Pediatric Gastroenterology and Nutrition
Objective:Various lines of evidence suggest that malfunctioning of the gut–liver axis contributes to hepatic damage of rodents and humans with nonalcoholic fatty liver disease. We evaluated the effects of short-term probiotic treatment in children with obesity-related liver disease who were noncompliant with lifestyle interventions. Patients and Methods:Twenty obese children (age 10.7 ± 2.1 years) with persisting hypertransaminasemia and ultrasonographic (US) bright liver were enrolled in this… 
View on Wolters Kluwer
hmphanmi.com.cn
246 Citations
Highly Influential Citations
11
Background Citations
80
Methods Citations
9
Results Citations
5

246 Citations

Citation Type

Citation Type

Beneficial Effect of Synbiotic Supplementation on Hepatic Steatosis and Anthropometric Parameters, But Not on Gut Permeability in a Population with Nonalcoholic Steatohepatitis
TLDR
It is concluded that synbiotic supplementation associated with nutritional counseling seems superior to nutritional counseling alone for NASH treatment as it attenuates steatosis and may help to achieve weight loss.
Effects of Probiotics on Nonalcoholic Fatty Liver Disease in Obese Children and Adolescents
TLDR
The present findings suggest that a course of the abovementioned probiotic compound can be effective in improving pediatric NAFLD.
Effects of Multistrain Probiotic Supplementation on Glycemic and Inflammatory Indices in Patients with Nonalcoholic Fatty Liver Disease: A Double-Blind Randomized Clinical Trial
TLDR
Considering the effects of probiotic supplementation on the reduction of glycemic and inflammatory indices in patients with NAFLD, consumption of probiotics is recommended as a complementary therapy in these patients.
Effect of probiotic supplementation in nonalcoholic steatohepatitis patients: PROBILIVER TRIAL protocol
TLDR
This work aims to evaluate the effects of probiotic supplementation on intestinal microbiota modulation, degree of hepatic steatosis and fibrosis, inflammation, gut permeability, and body composition in outpatients with a diagnosis of NASH.
THE THERAPEUTIC IMPACT OF PROBIOTICS ON NONALCOHOLIC FATTY LIVER DISEASE IN PEDIATRICS: A SYSTEMATIC REVIEW
TLDR
Probiotic therapy has contributed to the reduction of ALT serum levels in pediatric patients with nonalcoholic fatty liver disease, which is in line with results found by other authors in scientific literature.
Efficacy of Probiotics and Synbiotics in Patients with Nonalcoholic Fatty Liver Disease: A Meta-Analysis
Background and AimExtensive epidemiological evidence suggests that nonalcoholic fatty liver disease (NAFLD) is the primary chronic liver disease worldwide. However, some studies have showed…
Fighting Fatty Liver Diseases with Nutritional Interventions, Probiotics, Symbiotics, and Fecal Microbiota Transplantation (FMT).
TLDR
The current state of knowledge on the ways fatty liver diseases can be addressed with nutritional interventions, probiotics, symbiotics, and FMT is proposed.
Effects of probiotics on nonalcoholic fatty liver disease: a meta-analysis.
AIM To investigate the relationship between the gut-liver axis and nonalcoholic fatty liver disease (NAFLD), we performed a meta-analysis to evaluate the effects of probiotic therapy in NAFLD. …
Histological improvement of non-alcoholic steatohepatitis with a prebiotic: a pilot clinical trial
TLDR
Independent of weight loss, oligofructose improved liver steatosis relative to placebo and improved overall NAS score and prebiotic supplementation reduced histologically-confirmed Steatosis in patients with NASH.
Gut-liver axis and probiotics: their role in non-alcoholic fatty liver disease.
TLDR
Several lines of evidence are presented indicating that, by increasing energy extraction in some dysbiosis conditions or small intestinal bacterial overgrowth, specific gut microbiota and/or a "low bacterial richness" may play a role in obesity, metabolic syndrome, and fatty liver.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 33 REFERENCES
Beneficial Effects of a Probiotic VSL#3 on Parameters of Liver Dysfunction in Chronic Liver Diseases
TLDR
Results of the study suggest that manipulation of intestinal flora should be taken into consideration as possible adjunctive therapy in some types of chronic liver disease.
The role of the gut microbiota in nonalcoholic fatty liver disease
TLDR
Although the best evidence to support a role for the gut microbiota in NAFLD and NASH comes largely from animal models, data from studies in humans (albeit at times contradictory) is accumulating and could lead to new therapeutic avenues for these highly prevalent conditions.
Probiotics reduce the inflammatory response induced by a high-fat diet in the liver of young rats.
TLDR
The data suggest that VSL#3 administration could limit oxidative and inflammatory liver damage in patients with NAFLD.
High Prevalence of Small Intestinal Bacterial Overgrowth in Patients with Morbid Obesity: A Contributor to Severe Hepatic Steatosis
TLDR
In morbidly obese patients, bacterial overgrowth prevalence is higher than in healthy subjects and is associated with severe hepatic steatosis.
Elevated endotoxin levels in non-alcoholic fatty liver disease
TLDR
Results suggest elevated endotoxin may serve as an early indicator of potential liver damage, perhaps negating the need for invasive liver biopsy, and interventions aimed at reducing endotoxin levels in NAFLD patients may prove beneficial in reducing inflammatory burden.
Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
TLDR
The concept that intestinal bacteria induce endogenous signals that play a pathogenic role in hepatic insulin resistance and NAFLD are supported and novel therapies for these common conditions are suggested.
Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease
TLDR
In patients with NAFLD, both gut permeability and the prevalence of SIBO correlated with the severity of steatosis but not with presence of NASH, and the increased permeability appears to be caused by disruption of intercellular tight junctions in the intestine.
Pharmacological Interventions for Nonalcoholic Fatty Liver Disease in Adults and in Children: A Systematic Review
TLDR
Limited data do not allow one to draw firm conclusions on the efficacy of various treatments for NAFLD, and aspartate aminotransferase normalization was significantly higher in those treated with UDCA combined with vitamin E versus UDCA alone or placebo, and in those treating with metformin.
Small intestinal bacterial overgrowth, intestinal permeability, and non-alcoholic steatohepatitis
TLDR
The authors investigated whether intestinal permeability and circulating levels of endotoxin and tumour necrosis factor α are increased in NASH patients with SIBO compared with those without, and found that each of the double peaks in breath hydrogen values may occur after the arrival of the test meal at the caecum, paralleling delivery patterns of fermentable substrate to caecal bacteria.
Pediatric non-alcoholic fatty liver disease: preventive and therapeutic value of lifestyle intervention.
TLDR
The clinical course, pathogenesis and management of NAFLD in children, highlighting the preventive and therapeutic value of lifestyle intervention.
...
1
2
3
4
...