Effects of LY354740, a Novel Glutamatergic Metabotropic Agonist, on Nonhuman Primate Hypothalamic-Pituitary-Adrenal Axis and Noradrenergic Function

@article{Coplan2001EffectsOL,
  title={Effects of LY354740, a Novel Glutamatergic Metabotropic Agonist, on Nonhuman Primate Hypothalamic-Pituitary-Adrenal Axis and Noradrenergic Function},
  author={Jeremy D Coplan and Sanjay J. Mathew and E. Smith and Ronald C. Trost and Bruce A. Scharf and J M Martinez and Jack M. Gorman and James A. Monn and Darryle D. Schoepp and Leonard A. Rosenblum},
  journal={CNS Spectrums},
  year={2001},
  volume={6},
  pages={607 - 617}
}
Abstract The search for novel anxiolytics and antidepressants has focused on compounds with the potential to reduce excessive hypothalamic-pituitary-adrenal (HPA) axis activity. L-glutamate, an excitatory neurotransmitter ubiquitously present within the central nervous system, conceivably plays an important role in activating the neural sites involved in stress modulation. Deactivation of the HPA axis by glutamatergic neurotransmission modulation may represent a novel therapeutic approach… 
LY354740, an mGlu2/3 Receptor Agonist as a Novel Approach to Treat Anxiety/Stress
TLDR
Early clinical results with LY354740 have demonstrated safety and efficacy in a human anxiety model (panic provocation induced by CO 2 challenge), and data indicate mGlu2/3 receptor agonists such as LY 354740 represent a promising new approach for treatment of anxiety and stress-related disorders in humans.
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  • 2003
TLDR
The gamma-aminobutyric acid (GABA) system has long been targeted in anxiety interventions via benzodiazepine-GABA receptor antagonists and agents that target specific subunits of the GABA-A receptor and that manipulate GABA levels are developed.
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TLDR
This review highlights the best studied mGluR strategies for psychiatry, based on human molecular genetics, studies in animal models and preliminary clinical trials, and describes the potential value of mGLUR2 and mGlamR5 agonists and positive allosteric modulators for the treatment of schizophrenia.
Developmental expression of mGlu2 and mGlu3 in the mouse brain.
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