Effects of LHRH-analogues on mitogenic signal transduction in cancer cells.

  title={Effects of LHRH-analogues on mitogenic signal transduction in cancer cells.},
  author={Gu Nter Emons and Volkmar Mueller and Olaf Ortmann and Klaus Schulz},
  journal={The Journal of steroid biochemistry and molecular biology},
  volume={65 1-6},
The expression of luteinizing hormone-releasing hormone (LHRH) and its receptors has been demonstrated in a number of human malignant tumors, including cancers of the breast, ovary, endometrium and prostate. These findings suggest the presence of an autocrine regulatory system based on LHRH. Recent studies in our laboratory have demonstrated that the function of LHRH produced by ovarian cancer cells is the inhibition of their proliferation. Dose-dependent antiproliferative effects of LHRH… CONTINUE READING
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