Effects of L-prolyl-L-leucyl-glycine amide (MIF-I) on dopaminergic neurons.

  title={Effects of L-prolyl-L-leucyl-glycine amide (MIF-I) on dopaminergic neurons.},
  author={Richard M. Kostrzewa and M. A. Spirtes and J W Klara and Carl W Christensen and Abba J. Kastin and Tong H. Joh},
  journal={Pharmacology, biochemistry, and behavior},
  volume={5 Suppl 1},
In an attempt to determine the mechanism of action of L-proly-L-leucyl-glycine amide (MIF-I) in the treatment of Parkinson's disease, various parameters of dopaminergic neuronal function were studied in rats. It was found that the active uptake of 3H-dopamine (3H-DA) by synaptosome-rich homogenates of the striatum of rats treated with MIF-I (1 mg/kg IP X 3, 24 hr intervals) was unaltered 1 hr after final treatment with MIF-I. Also, neither tyrosine hydroxylase nor dopa decarboxylase activity… CONTINUE READING