Effects of L-dopa priming on cortical high beta and high gamma oscillatory activity in a rodent model of Parkinson's disease

@article{Dupre2016EffectsOL,
  title={Effects of L-dopa priming on cortical high beta and high gamma oscillatory activity in a rodent model of Parkinson's disease},
  author={Kristin B. Dupre and Ana V. Cruz and A Jeanene McCoy and Claire Delaville and Judith R. Walters},
  journal={Neurobiology of Disease},
  year={2016},
  volume={86},
  pages={1-15}
}
Prolonged L-dopa treatment in Parkinson's disease (PD) often leads to the expression of abnormal involuntary movements known as L-dopa-induced dyskinesia. Recently, dramatic 80 Hz oscillatory local field potential (LFP) activity within the primary motor cortex has been linked to dyskinetic symptoms in a rodent model of PD and attributed to stimulation of cortical dopamine D1 receptors. To characterize the relationship between high gamma (70-110 Hz) cortical activity and the development of L… CONTINUE READING
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