Effects of L-arginine and SIN-1 on sleep and waking in the rat during both phases of the light-dark cycle.

@article{Monti2004EffectsOL,
  title={Effects of L-arginine and SIN-1 on sleep and waking in the rat during both phases of the light-dark cycle.},
  author={Jaime M. Monti and H{\'e}ctor Jantos Jantos},
  journal={Life sciences},
  year={2004},
  volume={75 17},
  pages={2027-34}
}
The effects L-arginine (0.15-0.60 micromol), a nitric oxide precursor, and SIN-1 (3-morpholino-sydnonimine; linsidomine) (0.05-0.2 micromol), a nitric oxide donor, on spontaneous sleep were studied in adult rats implanted for chronic sleep recordings. L-arginine or SIN-1 given intracerebroventricularly during the light phase of the light-dark cycle induced no significant changes in sleep variables. On the other hand, administration of L-arginine or SIN-1 during the dark phase significantly… CONTINUE READING

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