Effects of L-Ascorbic Acid on Lysyl Oxidase in the Formation of Collagen Cross-links

  title={Effects of L-Ascorbic Acid on Lysyl Oxidase in the Formation of Collagen Cross-links},
  author={Miwa Kuroyanagi and E. Shimamura and M. Kim and N. Arakawa and Y. Fujiwara and Megumi Otsuka},
  journal={Bioscience, Biotechnology, and Biochemistry},
  pages={2077 - 2082}
  • Miwa Kuroyanagi, E. Shimamura, +3 authors Megumi Otsuka
  • Published 2002
  • Chemistry, Medicine
  • Bioscience, Biotechnology, and Biochemistry
  • To clarify the role of L-ascorbic acid (AsA) in the formation of pyridinoline, we examined the effects of AsA in vitro using soluble collagen and partially purified lysyl oxidase from bovine aorta. The concentration of dehydrodihydroxylysinonorleucine decreased when AsA was added in the early stage of pyridinoline formation. However, when AsA was added in a later stage of pyridinoline formation, the concentration of pyridinoline was not affected. These findings indicated that AsA was involved… CONTINUE READING
    14 Citations
    Effects of some vitamins on lactoperoxidase enzyme activity.
    • M. Şişecioğlu, M. Çankaya, H. Ozdemir
    • Chemistry, Medicine
    • International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
    • 2009
    • 10
    The lysyl oxidase like 2/3 enzymatic inhibitor, PXS‐5153A, reduces crosslinks and ameliorates fibrosis
    • 30
    Vitamin C in Health and Disease
    Endothelial cell adhesion, signaling, and morphogenesis in fibroblast-derived matrix.
    • 81
    Vitamin C, vitamin B12, folate and the risk of osteoporotic fractures. A case-control study.
    • 13
    Strawberry Genes and Genomics
    • 129


    The effect of L-ascorbic acid on age-related changes of pyridinoline in cartilage collagen of guinea pigs.
    • 4
    • PDF
    Development of a peroxidase-coupled fluorometric assay for lysyl oxidase.
    • 61
    Lysyl oxidase: properties, regulation and multiple functions in biology.
    • L. Smith-Mungo, H. Kagan
    • Biology, Medicine
    • Matrix biology : journal of the International Society for Matrix Biology
    • 1998
    • 492
    Structural and catalytic properties of copper in lysyl oxidase.
    • 110
    Nonpeptidyl amine inhibitors are substrates of lysyl oxidase.
    • 67
    • PDF