Effects of L-Ascorbic Acid on Lysyl Oxidase in the Formation of Collagen Cross-links

@article{Kuroyanagi2002EffectsOL,
  title={Effects of L-Ascorbic Acid on Lysyl Oxidase in the Formation of Collagen Cross-links},
  author={Miwa Kuroyanagi and E. Shimamura and M. Kim and N. Arakawa and Y. Fujiwara and Megumi Otsuka},
  journal={Bioscience, Biotechnology, and Biochemistry},
  year={2002},
  volume={66},
  pages={2077 - 2082}
}
  • Miwa Kuroyanagi, E. Shimamura, +3 authors Megumi Otsuka
  • Published 2002
  • Chemistry, Medicine
  • Bioscience, Biotechnology, and Biochemistry
    • To clarify the role of L-ascorbic acid (AsA) in the formation of pyridinoline, we examined the effects of AsA in vitro using soluble collagen and partially purified lysyl oxidase from bovine aorta. The concentration of dehydrodihydroxylysinonorleucine decreased when AsA was added in the early stage of pyridinoline formation. However, when AsA was added in a later stage of pyridinoline formation, the concentration of pyridinoline was not affected. These findings indicated that AsA was involved… CONTINUE READING
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