Effects of L-5HTP With and Without Carbidopa on Plasma β-Endorphin and Pain Perception: Possible Implications in Migraine Prophylaxis

@article{Genazzani1986EffectsOL,
  title={Effects of L-5HTP With and Without Carbidopa on Plasma $\beta$-Endorphin and Pain Perception: Possible Implications in Migraine Prophylaxis},
  author={A. R. Genazzani and Giorgio Sandrini and Fabio Facchinetti and Vittoria Rizzo and Enrico Alfonsi and Grazia Sances and Menotti Calvani and Giuseppe Nappi},
  journal={Cephalalgia},
  year={1986},
  volume={6},
  pages={175 - 179}
}
L-Tryptophan (L-TP) has been used in migraine and other pain conditions. The mechanism underlying the analgesic effect is still partly undefined. In this study the effects of subchronic administration of L-5-hydroxytryptophan (L-5HTP) (with and without carbidopa) on plasma β-endorphin (b-EP) levels and subjective pain threshold and tolerance were investigated in seven healthy volunteers. To measure also an objective indicator of pain, the nociceptive flexion reflex threshold was studied. L-5HTP… Expand
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References

SHOWING 1-10 OF 29 REFERENCES
Stimulation of beta-endorphin and beta-lipotropin release from the anterior but not the neurointermediate pituitary lobe in the rat after acute administration of serotonin-acting drugs.
TLDR
It is concluded that brain serotonin neurons exert a stimulatory influence on β-EP and β-LPH release from the AP but, likely, not from the NIL and that hypothalamic endorphins are not implicated in the secretory events occuring at AP level after acute activation of 5-HT neurotransmission. Expand
Serotonergic mechanism in the control of beta-endorphin and ACTH release in male rats.
TLDR
The results suggest that 5-HT is a potent stimulator of both beta-EP and ACTH release and the increase in plasma concentrations of ACTH andbeta-EP induced by stress are probably mediated, at least in part, by central serotonergic mechanisms. Expand
5-Hydroxytryptophan in the prophylaxis of migraine
TLDR
The statistical evaluation shows significant differences between control and treatment periods, and no difference between methysergide and 5- HTP periods, which could support the serotonin theory of migraine, pointing out a possible brain 5-HT deficiency, and consequently central monoamine supersensitivity. Expand
Serotoninergic agonists increase plasma levels of beta-endorphin and beta-lipotropin in humans.
TLDR
Plasma cortisol levels changed similarly to those of beta-EP and beta-LPH in all the experiments, indicating that putative serotoninergic drugs exert a positive role on the various corticotropin-releasing hormone-mediated secretions. Expand
Concomitant increase in nociceptive flexion reflex threshold and plasma opioids following transcutaneous nerve stimulation
TLDR
The data indicate that the so‐called post‐stimulation analgesia could be supported by the enhancement of the endogenous opioid system. Expand
Progressive impairment of CSF β-EP levels in migraine sufferers
TLDR
Data showing that the progressive evolution of migraine is concomitant with a progressive impairment in the CSF levels of &bgr;‐EP, sustain the concept that non‐organic central pain is related to a reduced activity of the neurons responsible for theCSF content of & bgr;-EP. Expand
Electrophysiological evidence for a possible serotonergic involvement in some endogenous opiate activity in humans.
TLDR
The effects of indalpine (a selective 5-HT uptake inhibitor) on the threshold of lower limb nociceptive flexion reflexes were studied (double blind) in humans and a significant naloxone-reversible depression (threshold increased) of the nOCiceptive reflexes was found. Expand
Electrophysiological evidence for a release of endogenous opiates in stress-induced‘Analgesia’ in man
TLDR
The data strongly suggest that endogenous opioids are involved in the phenomenon of stress-induced analgesia in man and show that the release of opiates in these conditions possibly modulates non-specific structures which are known to be activated during stress or emotion. Expand
L-5HTP Treatment in Primary Headaches: An Attempt at Clinical Identification of Responsive Patients
TLDR
The emerging profile of the responsive patients is characterized by such peculiar traits as prevalence of previous major mood disturbances and minor frequency of anxiety, longer duration of the illness and higher occurrence of some associated symptoms, lower incidence of exogenous and hormonal trigger factors, and previously positive response to pizotifen treatment. Expand
Antinociceptive activity of morphine after injection of biogenic amines in the cerebral ventricles of the conscious rat
TLDR
It is suggested that the antinociceptive effect of morphine may depend on the balance between the concentrations of 5‐HT and NA in the brain. Expand
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