Effects of L-5HTP With and Without Carbidopa on Plasma β-Endorphin and Pain Perception: Possible Implications in Migraine Prophylaxis

  title={Effects of L-5HTP With and Without Carbidopa on Plasma $\beta$-Endorphin and Pain Perception: Possible Implications in Migraine Prophylaxis},
  author={A. R. Genazzani and Giorgio Sandrini and Fabio Facchinetti and Vittoria Rizzo and Enrico Alfonsi and Grazia Sances and Menotti Calvani and Giuseppe Nappi},
  pages={175 - 179}
L-Tryptophan (L-TP) has been used in migraine and other pain conditions. The mechanism underlying the analgesic effect is still partly undefined. In this study the effects of subchronic administration of L-5-hydroxytryptophan (L-5HTP) (with and without carbidopa) on plasma β-endorphin (b-EP) levels and subjective pain threshold and tolerance were investigated in seven healthy volunteers. To measure also an objective indicator of pain, the nociceptive flexion reflex threshold was studied. L-5HTP… Expand
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Antinociceptive activity of morphine after injection of biogenic amines in the cerebral ventricles of the conscious rat
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