Effects of Kupffer cell depletion on acute alpha-naphthylisothiocyanate-induced liver toxicity in male mice.

@article{Cullen2013EffectsOK,
  title={Effects of Kupffer cell depletion on acute alpha-naphthylisothiocyanate-induced liver toxicity in male mice.},
  author={John M Cullen and Brenda Faiola and David H Melich and Richard A. Peterson and Holly Lynn Jordan and Carie Lynette Kimbrough and Judith S Prescott and Richard Thomas Miller},
  journal={Toxicologic pathology},
  year={2013},
  volume={41 1},
  pages={7-17}
}
Depletion of Kupffer cells, known to modulate chemical-induced hepatocellular injury, has not been studied with regard to biliary epithelial injury. Here, the authors investigated the effect of Kupffer cell depletion by clodronate on the toxicity of alpha-naphthylisothiocyanate (ANIT), known to injure biliary epithelium as well as hepatocytes. Up to 99… CONTINUE READING