Effects of Koumine on Adjuvant- and Collagen-Induced Arthritis in Rats.

@article{Yang2016EffectsOK,
  title={Effects of Koumine on Adjuvant- and Collagen-Induced Arthritis in Rats.},
  author={Jian Yang and Hong-da Cai and Yu-Lan Zeng and Ze-Hong Chen and Meng-Han Fang and Yan-Ping Su and Hui-Hui Huang and Ying Xu and Changxi Yu},
  journal={Journal of natural products},
  year={2016},
  volume={79 10},
  pages={2635-2643}
}
To examine the effect of koumine, a Gelsemium alkaloid, on two experimental models of rheumatoid arthritis (RA), rats with adjuvant-induced arthritis (AIA) and collagen-induced arthritis (CIA) were administered koumine (0.6, 3, or 15 mg/kg/day) or vehicle through gastric gavage (i.g.). Clinical evaluation was performed via measurements of hind paw volume… CONTINUE READING