Effects of Klotho on fibrosis and cancer: A renal focus on mechanisms and therapeutic strategies.

Abstract

Klotho is a membrane-bound protein predominantly expressed in the kidney, where it acts as a permissive co-receptor for Fibroblast Growth Factor 23. In its shed form, Klotho exerts anti-fibrotic effects in several tissues. Klotho-deficient mice spontaneously develop fibrosis and Klotho deficiency exacerbates the disease progression in fibrotic animal models… (More)
DOI: 10.1016/j.addr.2017.07.009

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