Effects of KATP channel modulators on acetylcholine release from guinea-pig isolated atria and small intestine

Abstract

The effects of KATP channel blockers (glibenclamide, HMR 1883, HMR 1372) and openers (cromakalim, pinacidil, diazoxide) on the electrically-evoked (5 Hz) release of [3H]acetylcholine were studied in isolated guinea-pig atria and myenteric plexus-longitudinal muscle preparations which had been preincubated with [3H]choline. Atria: Cromakalim (0.3 µM and 1 µM… (More)
DOI: 10.1007/s00210-002-0539-9

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