Effects of K+-deficiency and serum supplementation on protein turnover and nucleic acid synthesis in HeLa cells.

@article{Sakai1985EffectsOK,
  title={Effects of K+-deficiency and serum supplementation on protein turnover and nucleic acid synthesis in HeLa cells.},
  author={Takuo Sakai and Toshitaka Ikehara and Hisao Yamaguchi and N. Ohsaka and Hiroshi Miyamoto},
  journal={Life sciences},
  year={1985},
  volume={36 2},
  pages={
          169-76
        }
}
When most of the K+ in a chemically defined medium was replaced with Rb+, cell growth of HeLa cells was strongly inhibited. The growth was partially but significantly restored by an addition of 5% dialyzed calf serum to the medium. The inhibition of cell growth in Rb+-substituted medium was partly due to suppression of protein synthesis by K+ deficiency, but the key mechanism of inhibition is still unknown. Rb+ substitution did not influence protein degradation or nucleic acid synthesis. The… CONTINUE READING
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