Effects of K+-channel blockers on transmitter release in bullfrog sympathetic ganglia.

@article{Kumamoto1985EffectsOK,
  title={Effects of K+-channel blockers on transmitter release in bullfrog sympathetic ganglia.},
  author={Eiichi Kumamoto and Kenji Kuba},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1985},
  volume={235 1},
  pages={241-7}
}
Effects of K+-channel blockers, tetraethylammonium (TEA), 4-aminopyridine (4-AP) and Cs+ on synaptic transmission were studied with an intracellular electrode in bullfrog sympathetic ganglia. TEA (25-500 microM), 4-AP (0.6-5 microM) and Cs+ (50 microM-10 mM) all increased the quantal content of the fast excitatory postsynaptic potential in a dose-dependent manner. The effects of TEA were rapid in onset and recovery, whereas those of 4-AP and Cs+ appeared with a notable delay and reversed slowly… CONTINUE READING

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