Effects of K+ channel blockers on inwardly and outwardly rectifying whole-cell K+ currents in sheep parotid secretory cells

@article{Ishikawa1993EffectsOK,
  title={Effects of K+ channel blockers on inwardly and outwardly rectifying whole-cell K+ currents in sheep parotid secretory cells},
  author={Toru Ishikawa and David I. Cook},
  journal={The Journal of Membrane Biology},
  year={1993},
  volume={133},
  pages={29-41}
}
We have used whole-cell patch-clamp techniques to examine the sensitivities of the inwardly and the outwardly rectifying K+ currents in sheep parotid cells to K+ channel blockers. Extracellular tetraethylammonium (ID50 ≈ 200 μmol/liter), quinine (ID50 ≈ 100 μmol/liter), verapamil (ID50 ≈ 30 μmol/liter) and charybdotoxin (ID50 < 0.1 μmol/liter) reduced the outwardly rectifying current but had no effect on the inwardly rectifying current. Quinidine inhibited the outwardly rectifying current (ID50… CONTINUE READING
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Cation channels and secretion

  • D. I. Cook, J. A. Young
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  • 1990
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