Effects of Isotretinoin on Meibomian Glands

@article{Moy2015EffectsOI,
  title={Effects of Isotretinoin on Meibomian Glands},
  author={Allison Moy and Nancy A McNamara and Meng C Lin},
  journal={Optometry and Vision Science},
  year={2015},
  volume={92},
  pages={925–930}
}
ABSTRACT The authors have reviewed the potential etiology and long-standing consequences of isotretinoin use in the development of dry eye symptoms in the absence of significant clinical findings. Despite the normal appearance of meibomian gland structure on meibography and minimal signs of eyelid margin inflammation, the secretory function of these glands is reduced and symptoms of dryness can greatly impact a patient’s quality of life. The available literature indicates that isotretinoin’s… Expand
The effect of oral isotretinoin therapy on meibomian gland morphology and dry eye tests.
TLDR
The morphologic analysis using non-contact meibography is a useful method for assessing isotretinoin-related changes in MGs. Expand
Evaluation of dry eye disase and meibomian gland dysfunction with meibography in seborrheic dermatitis.
TLDR
Patients with Seborrheic Dermatitis should be evaluated for meibomian gland dysfunction and dry eye disase, and start treatment when needed. Expand
Blepharospasm induced by systemic isotretinoin
TLDR
This is the first clinical case of blepharospasm induced by isotretinoin, a movement disorder characterized by hyperactivity of orbicularis oculi and other muscles around the eye, which is resistant to other treatments. Expand
Isotretinoin and the eye: A review for the dermatologist
TLDR
The aim of this review is to present an up‐to‐date overview for the dermatologist about the prevention, diagnosis, and treatment of the ocular side effects of isotretinoin, and when to refer to the eye specialist. Expand
Histopathology and selective biomarker expression in human meibomian glands
TLDR
The histopathological features of meibomian gland (MG) tissue from cadaver donors are examined to identify potential pathogenic processes that underlie MGD in humans, and potentially distinct pathogenic mechanisms in MGD are suggested. Expand
Role of topical dehydroepiandrosterone in ameliorating isotretinoin-induced Meibomian gland dysfunction in adult male albino rat.
  • M. Ibrahim, Walaa M. Elwan
  • Biology, Medicine
  • Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft
  • 2017
TLDR
Topical DHEA could prove to be beneficial in ameliorating isotretinoin-induced Meibomian gland dysfunction most probably through its androgenic effect. Expand
Reduced ocular surface disease index (OSDI) scores in patients with isotretinoin treatment
TLDR
The OSDI test can be used as a diagnostic test for patients receiving systemic isotretinoin treatment and there were significant differences in the average OSDI score, the average meibomian gland disease (MGD) grade and average BUT value of both eyes during the treatment compared with baseline values. Expand
Ocular surface inflammation impairs structure and function of meibomian gland.
TLDR
Dysfunction of the meibomian glands alters secreted meibum quantitatively and qualitatively that can lead to damage to the ocular surface epithelium, leading to secondary ocular inflammation. Expand
An Eyelid Warming Device for the Management of Meibomian Gland Dysfunction
TLDR
The EyeBag may relieve symptoms of dry eye, but the effect on meibomian gland function and tear stability when used for only 4 weeks was undetectable. Expand
Proteolytic activity in the meibomian gland: Implications to health and disease.
  • P. Argüeso
  • Biology, Medicine
  • Experimental eye research
  • 2017
TLDR
Deciphering the role of proteolytic activity in the meibomian gland offers an opportunity to gain a more comprehensive and fundamental understanding of the developmental, physiological, and pathological processes associated with this gland. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 90 REFERENCES
The international workshop on meibomian gland dysfunction: report of the subcommittee on the epidemiology of, and associated risk factors for, MGD.
TLDR
Although the etiology of MGD may differ from that of aqueous-deficient dry eye disease (which is due to insufficient lacrimal gland production), the two conditions share many clinical features, including symptoms of ocular surface irritation and visual fluctuation, altered tear film stability, and potential ocularsurface compromise. Expand
Nonobvious Obstructive Meibomian Gland Dysfunction
TLDR
This review presents the rationale and supporting data for a recent paradigm shift in the understanding of meibomian gland dysfunction, and presents the specific treatment of NOMGD, emphasizing that the success of treatment of all forms of obstructive MGD is dependent on the relief of the obstruction. Expand
The international workshop on meibomian gland dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the meibomian gland.
TLDR
It is accepted that MGD is important, conceivably underestimated, and possibly the most frequent cause of dry eye disease due to increased evaporation of the aqueous tears, and a comprehensive review of physiological and pathophysiological aspects of the meibomian glands is sought. Expand
Meibomian Gland Dysfunction in Chronic Blepharitis
TLDR
It is found that tear osmolarity correlated positively with gland dropout and negatively with excreta volume, which supports the significance of meibomian gland dysfunction on tear oSMolarity and the evaporative state of the eye. Expand
Tear secretion and lacrimal gland function of rabbits treated with isotretinoin.
TLDR
It is concluded that isotretinoin is not toxic to the lacrimal gland of rabbits, which suggests that ocular irritation in patients treated with isot Retinol is not caused by decreased tear secretion during therapy. Expand
Isotretinoin Use in Acne: Prospective Evaluation of Adverse Events
TLDR
This prospective analysis has shown that patients treated with isotretinoin experienced a predictable series of side effects, some occurred fleetingly, but several persisted for the duration of treatment. Expand
Meibomian gland dysfunction and contact lens intolerance.
TLDR
Clinical and cytologic studies indicate that a syndrome characterized by deficient or inadequate Meibomian gland secretions, minimal or transient symptoms suggestive of ocular dryness, fluorescein staining of the cornea, and contact lens intolerance is due to obstruction of the Meiboian gland orifices by desquamated epithelial cells that tend to aggregate in keratotic clusters. Expand
Analysis of common side effects of isotretinoin.
  • J. McLane
  • Medicine
  • Journal of the American Academy of Dermatology
  • 2001
TLDR
Because of its relatively rapid onset of action and its high efficacy with reducing more than 90% of the most severe inflammatory lesions, Accutane has a role as an effective treatment in patients with severe acne that is recalcitrant to other therapies. Expand
Ocular surface changes and discomfort in patients with meibomian gland dysfunction.
TLDR
Meibomian gland dysfunction is a major cause of ocular surface abnormalities and ocular discomfort and the rate of tear production was increased more in the gland dropout group than in the non-MGD group. Expand
The international workshop on meibomian gland dysfunction: report of the subcommittee on management and treatment of meibomian gland dysfunction.
The goals of the subcommittee were to review the current practice and published evidence of medical and surgical treatment options for meibomian gland dysfunction (MGD) and to identify areas withExpand
...
1
2
3
4
5
...