Effects of Isotretinoin on Meibomian Glands

  title={Effects of Isotretinoin on Meibomian Glands},
  author={Allison Moy and Nancy A McNamara and Meng C Lin},
  journal={Optometry and Vision Science},
ABSTRACT The authors have reviewed the potential etiology and long-standing consequences of isotretinoin use in the development of dry eye symptoms in the absence of significant clinical findings. Despite the normal appearance of meibomian gland structure on meibography and minimal signs of eyelid margin inflammation, the secretory function of these glands is reduced and symptoms of dryness can greatly impact a patient’s quality of life. The available literature indicates that isotretinoin’s… 

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  • 2017

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  • J. McLane
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    Journal of the American Academy of Dermatology
  • 2001
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