Effects of Isometric Exercise on the End‐Diastolic Pressure, Volumes, and Function of the Left Ventricle in Man

@article{Flessas1976EffectsOI,
  title={Effects of Isometric Exercise on the End‐Diastolic Pressure, Volumes, and Function of the Left Ventricle in Man},
  author={A P Flessas and Gilbert P. Connelly and Shunnosuke Handa and C Tilney and Colleen K. Kloster and Rachel Rimmer and John F. Keefe and Michael D. Klein and Thomas J. Ryan},
  journal={Circulation},
  year={1976},
  volume={53},
  pages={839–847}
}
Changes induced in left ventricular (LV) hemodynamics by isometric exercise were analyzed in 43 patients: 30 with coronary heart disease (CAD), four with noncoronary heart disease, nine normal. Volumes were angiographically determined and correlated with left ventricular end-diastolic pressure (LVEDP) both at rest and during the fifth minute of 30% sustained handgrip (HNG). All normals and eight with CAD improved LV function during HNG. LVEDP decreased or remained constant, end-diastolic volume… 
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Modification of Left Ventricular Diastolic Behavior by Isometric Handgrip Exercise
To clarify the basis of increased left ventricular (LV) end-diastolic pressure associated with isometric exercise, LV diastolic and systolic function were examined in 25 patients during sustained…
Noninvasive assessment of changes in left ventricular function induced by graded isometric exercise in healthy subjects.
TLDR
The effect of isometric exercise on left ventricular performance depends, to some extent, on the relative strength of muscle contraction, and in healthy subjects, isometric Exercise of low intensity (less 40 percent of MVC) does not generally result in depression ofleft ventricular function.
Left ventricular responses to upright isometric handgrip and deadlift in men with coronary artery disease.
Effects of the cold pressor test on the left ventricular function of patients with coronary artery disease.
Cardiovascular responses to isometric exercise in patients with mitral stenosis. Comparison with normal subjects and patients with depressed ejection fraction.
TLDR
It is concluded that patients with MS demonstrate a normal chronotropic and pressor response to isometric exercise and normal left ventricular end-diastolic pressure response toIsometric handgrip stress in patients withMS suggests goodleft ventricular performance.
Effect of Angina on the Left Ventricular Diastolic Pressure‐Volume Relationship
TLDR
The data indicate that the increasedleft ventricular diastolic pressure during myocardial ischemia is the result of both impaired left ventricular systolic performance and altered left ventriculograms, and therefore pressure was higher during angina.
Effects of nitroglycerin on isometric exercise.
Left ventricular diastolic properties and filling characteristics during spontaneous angina pectoris at rest.
Cineventriculographic analysis of left ventricular dynamics during sustained handgrip exercise.
TLDR
The data signify that an increased afterload induced by handgrip leads to an enhanced left ventricular myocardial contraction in addition to an increase in preload in the normal group, while the Frank-Starling mechanism is mainly utilized in the patient group.
Diastolic pressure‐volume relationship during handgrip exercise in patients with coronary artery disease
TLDR
Isometric handgrip exercise resulted in an upward shift in the diastolic pressure‐volume curve in patients with coronary artery disease, and complete relaxation and/or the viscoelastic properties of the left ventricle associated with ischemia could be responsible for this phenomenon.
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References

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TLDR
Normal hearts responded to IHG by increasing CI through tachycardia and pumping the same SI against increased afterload, without utilizing diastolic volume reserves, to support the hypothesis that isometric muscular exercise leads to an augmentation of LV myocardial contractility in normal man.
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TLDR
The observations suggest that the normal physiological response to isometric exertion includes a major increase in left ventricular myocardial contractility, and appears sufficient to account completely for the increased ventricular performance associated with handgrip exercise.
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TLDR
The stress imposed by sustained handgrip provides a simple test for the evaluation of left ventricular reserve and correlated well with the New York Heart Association functional classification of the patient studied.
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TLDR
Sustained isometric handgrip exercise was studied in 28 patients, 19 with and nine without catheterization evidence of heart disease, and ability to distinguish normal and abnormal ventricular performance, sustained hand grip is a valuable new stress test.
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  • Medicine, Biology
    Circulation
  • 1970
TLDR
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TLDR
Isometric handgrip exercise evoked a lesser increase in heart rate and cardiac output than did submaximal dynamic (treadmill) exercise but resulted in a more potent systemic pressor response.
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TLDR
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TLDR
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