Effects of Intermittent Fasting on Health, Aging, and Disease.

@article{deCabo2019EffectsOI,
  title={Effects of Intermittent Fasting on Health, Aging, and Disease.},
  author={Rafael de Cabo and Mark P. Mattson},
  journal={The New England journal of medicine},
  year={2019},
  volume={381 26},
  pages={
          2541-2551
        }
}
Effects of Intermittent Fasting on Health and Aging Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base... 
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491 Citations
Highly Influential Citations
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Background Citations
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Results Citations
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References

SHOWING 1-10 OF 82 REFERENCES

Caloric Intake and Aging

In postindustrial societies, overeating, inactivity, and obesity have emerged as new challenges in public health.1,2 Considerable effort is now being devoted to determining the pathophysiologic con...

Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake

In conclusion, intermittent fasting resulted in beneficial effects that met or exceeded those of caloric restriction including reduced serum glucose and insulin levels and increased resistance of neurons in the brain to excitotoxic stress in these mice.

Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin

The effectiveness of therapeutic fasting to reverse their insulin resistance is demonstrated, resulting in cessation of insulin therapy while maintaining control of their blood sugars.

Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism.

Alternate-day fasting was feasible in nonobese subjects, and fat oxidation increased, however, hunger on fasting days did not decrease, perhaps indicating the unlikelihood of continuing this diet for extended periods of time.

Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes.

A time to fast

Future research endeavors should be directed to the integration of a balanced nutritious diet with controlled meal size and patterns and periods of fasting to develop better strategies to prevent, postpone, and treat the socioeconomical burden of chronic diseases associated with aging.

Fasting: molecular mechanisms and clinical applications.

Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma.

Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males

The results suggest that an intermittent fasting program in which all calories are consumed in an 8-h window each day, in conjunction with resistance training, could improve some health-related biomarkers, decrease fat mass, and maintain muscle mass in resistance-trained males.

Improvement in coronary heart disease risk factors during an intermittent fasting/calorie restriction regimen: Relationship to adipokine modulations

It is suggested that IFCR with a liquid diet favorably modulates visceral fat and adipokines in a way that may confer protection against CHD.
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