Effects of Intermittent Fasting on Health, Aging, and Disease.
@article{deCabo2019EffectsOI, title={Effects of Intermittent Fasting on Health, Aging, and Disease.}, author={Rafael de Cabo and Mark P. Mattson}, journal={The New England journal of medicine}, year={2019}, volume={381 26}, pages={ 2541-2551 } }
Effects of Intermittent Fasting on Health and Aging Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base...
461 Citations
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Intermittent fasting has beneficial effects equivalent to those of caloric restriction in terms of body weight control, improvements in glucose homeostasis and lipid profiles, and anti-inflammatory effects.
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Late-life initiated EOD fasting is sufficient to reduce aging-related frailty, at least in males, and suggests that renal H2S production capacity may modulate the effects of late-life E OD fasting on frailty.
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The present review will investigate the effects of the main forms of fasting, activating the metabolic switch from glucose to fat and ketones (G-to-K), starting 12–16 h after cessation or strong reduction of food intake.
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Coupling periodic and prolonged, or intermittent and more frequent cycles of fasting or fasting-mimicking diets, designed to maximize compliance and minimize side effects, has the potential to play a central role in the prevention and treatment of CVD and metabolic syndrome.
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