Effects of Inhibiting VPS4 Support a General Role for ESCRTs in Extracellular Vesicle Biogenesis.

@article{Jackson2017EffectsOI,
  title={Effects of Inhibiting VPS4 Support a General Role for ESCRTs in Extracellular Vesicle Biogenesis.},
  author={Charles E. Jackson and Benjamin S. Scruggs and Jean E Schaffer and Phyllis I Hanson},
  journal={Biophysical journal},
  year={2017},
  volume={113 6},
  pages={
          1342-1352
        }
}
Extracellular vesicles (EVs) are proposed to play important roles in intercellular communication. Two classes of EVs can be distinguished based on their intracellular origin. Exosomes are generated within endosomes and released when these fuse with the plasma membrane, whereas ectosomes bud directly from the plasma membrane. Studies of EV function have been hindered by limited understanding of their biogenesis. Components of the endosomal sorting complex required for transport (ESCRT) machinery… CONTINUE READING
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