Effects of Iminodipropionitrile on Cerebral Amino Acid Levels

  title={Effects of Iminodipropionitrile on Cerebral Amino Acid Levels},
  author={Eugene Toth and Abel Lajtha and E. Sylvester Vizi},
  journal={Brain Research Bulletin},
Iminodipropionitrile (IDPN), a compound that causes dyskinetic symptoms in animals and has possible use as a model for human dyskinesia, was tested in mice and rats for its effect on cerebral amino acids. In mice, 2 h after IDPN administration, the level of total brain alanine was reduced; after 5 h the levels of aspartic acid and glutamic acid were also reduced, and the level of glutamine was increased. In rats, after chronic administration of IDPN, the level of glutamic acid in the total… CONTINUE READING