Effects of Ibudilast on the Subjective, Reinforcing, and Analgesic Effects of Oxycodone in Recently Detoxified Adults with Opioid Dependence

  title={Effects of Ibudilast on the Subjective, Reinforcing, and Analgesic Effects of Oxycodone in Recently Detoxified Adults with Opioid Dependence},
  author={Verena E Metz and J. Jones and J. Manubay and M. Sullivan and S. Mogali and Andrew Segoshi and Gabriela Madera and K. W. Johnson and S. Comer},
  • Verena E Metz, J. Jones, +6 authors S. Comer
  • Published 2017
  • Medicine
  • Neuropsychopharmacology
  • Ibudilast, a nonselective phosphodiesterase inhibitor, is used clinically in Asia for the treatment of asthma and poststroke dizziness. Recent preclinical studies have suggested that it also inhibits glial cell activation in rodents, and may alter opioid-mediated effects, including analgesia and withdrawal symptoms. The effects of ibudilast on the abuse potential of opioids in humans are largely unknown. The present study was designed to examine the influence of ibudilast on subjective… CONTINUE READING
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