Effects of IL-6 on pyruvate dehydrogenase regulation in mouse skeletal muscle

  title={Effects of IL-6 on pyruvate dehydrogenase regulation in mouse skeletal muscle},
  author={Rasmus Sj\orup Biens\o and Jakob G Knudsen and Nina Brandt and Per Amstrup Pedersen and Henriette Pilegaard},
  booktitle={Pfl{\"u}gers Archiv - European Journal of Physiology},
Skeletal muscle regulates substrate choice according to demand and availability and pyruvate dehydrogenase (PDH) is central in this regulation. Circulating interleukin (IL)-6 increases during exercise and IL-6 has been suggested to increase whole body fat oxidation. Furthermore, IL-6 has been reported to increase AMP-activated protein kinase (AMPK) phosphorylation and AMPK suggested to regulate PDHa activity. Together, this suggests that IL-6 may be involved in regulating PDH. The aim of this… CONTINUE READING
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