Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome.

@article{Biron1995EffectsOI,
  title={Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome.},
  author={Christine A. Biron A. Biron and Ricardo Tostes Gazzinelli},
  journal={Current opinion in immunology},
  year={1995},
  volume={7 4},
  pages={485-96}
}
Recent studies have documented that the immunoregulatory functions of IL-12 may play a role in promoting endogenous protective responses during infections and/or contribute to pathology resulting from unregulated cytokine expression. Pathogen induction of IL-12 elicits interferon-gamma production by natural killer cells, which contributes to early defense during certain bacterial, parasitic, and viral infections. IL-12 also facilitates the development of T helper type 1 (Th1) lymphocytes… CONTINUE READING

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