Corpus ID: 102414415

Effects of IHC-72 on the ventricular muscle contraction induced by isoproterenol, calcium and histamine in guinea pigs

@article{Ji1992EffectsOI,
  title={Effects of IHC-72 on the ventricular muscle contraction induced by isoproterenol, calcium and histamine in guinea pigs},
  author={G. Ji and De-hua Zhao and De-qiang Liu and B. Sheng},
  journal={Journal of the Fourth Military Medical University},
  year={1992},
  volume={13},
  pages={210-212}
}
The effects of 3, 6(dimethylamino)-dibenzopyriodonium edetate (IHC 72) on the dose-response curves of isoproterenol, calcium and histamine in guinea-pig papillary muscles were studied. When isoproterenol dose-response curves were shifted to the right, the maximal response was depressed, the pD_(2) value was 3.94; IHC-72 and verapamil antagonized the effect of calcium non-conpetivcly, the pD_(2) values were 4.26 and 5.60 respectively. IHC-72 could also make the dose-response curves of histamine… Expand