Effects of IGFBP-2 overexpression in vitro and in vivo

@article{Wolf2000EffectsOI,
  title={Effects of IGFBP-2 overexpression in vitro and in vivo},
  author={Eckhard Wolf and Harald Lahm and M. Wu and R. Wanke and Andreas Hoeflich},
  journal={Pediatric Nephrology},
  year={2000},
  volume={14},
  pages={572-578}
}
Abstract Insulin-like growth factor-binding proteins (IGFBPs) are important modulators of IGF actions and may have both stimulatory and inhibitory effects. Expression of IGFBP-2 is increased after fasting and in a variety of pathological conditions. However, the specific role of IGFBP-2 in growth physiology remains to be determined. In this review, we summarize data from in vitro and in vivo models suggesting that IGFBP-2 has mainly inhibitory effects on IGF actions. Since the growth hormone… 
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