Effects of Hypoxia on the Activity of the Dopaminergic Neuron System in the Rat Striatum as Studied by In Vivo Brain Microdialysis

@article{Akiyama1991EffectsOH,
  title={Effects of Hypoxia on the Activity of the Dopaminergic Neuron System in the Rat Striatum as Studied by In Vivo Brain Microdialysis},
  author={Yoshinori Akiyama and Kunio Koshimura and Tetsuya Ohue and K. Lee and Soichi Miwa and Sen Yamagata and Haruhiko Kikuchi},
  journal={Journal of Neurochemistry},
  year={1991},
  volume={57}
}
The purpose of the present study is to clarify the effects of hypoxia on the activity of the dopaminergic neurons in the brain and its mechanism of action. For this purpose, the effects of hypoxia on the extracellular levels of 3,4‐dihy‐droxyphenylethylamine (dopamine) were examined in the rat Striatum using in vivo brain microdialysis in the presence or absence of pretreatment with either tetrodotoxin (a blocker of voltage‐dependent sodium channels) or nomifensine (a blocker of dopamine… 
Modification of the striatal dopaminergic neuron system by carbon monoxide exposure in free-moving rats, as determined by in vivo brain microdialysis
TLDR
It is suggested that CO exposure may stimulate Na+-dependent DA release in addition to suppressing DA metabolism, resulting in a marked increase in extracellular DA in rat striatum, and CO withdrawal and subsequent reoxygenation may enhance the oxidative metabolism, preferentially mediated by MAO-A, of the increased extacellular DA.
Effects of Graded Levels of Tissue Oxygen Pressure on Dopamine Metabolism in the Striatum of Newborn Piglets
TLDR
The marked effects of mild tissue hypoxia on both the extracellular dopamine concentration and dopamine metabolism indicate that the metabolic consequences of decreased tissue oxygen pressure extend to higher values than generally appreciated.
Effect of Carbon Monoxide on Dopamine and Glutamate Uptake and cGMP Levels in Rat Brain
TLDR
Findings suggest a role for CO in trans-synaptic regulation through modulation of DA and Glu transporters and of cGMP levels; the effect on cG MP levels is independent of NOS activity and appears to be sexually dimorphic and region specific.
Effects of carotid sinus nerve transection on changes in neuropeptide Y and indolamines induced by long-term hypoxia in rats
TLDR
It is proposed that long-term hypoxia alters brain NPY-LI and indolamine content through the stimulation of CB chemoreceptors or ancillary chemoreCEPTors, as well as through local biochemical or morphological mechanisms.
...
...

References

SHOWING 1-10 OF 48 REFERENCES
Effects of Hypoxia on the Activities of Noradrenergic and Dopaminergic Neurons in the Rat Brain
TLDR
The results suggest that although hypoxia decreases the biosynthesis of both NA and DA, the effects of oxygen depletion on the functional activities of NA neurons differ considerably from those of DA neurons: Only in the cerebral cortex and hippocampus are the NA neurons slightly sensitive to Hypoxia, whereas the DA neurons are most sensitive in all brain regions.
Effects of Choline Administration on In Vivo Release and Biosynthesis of Acetylcholine in the Rat Striatum as Studied by In Vivo Brain Microdialysis
The purpose of the present study is to clarify the effects of the administration of choline on the in vivo release and biosynthesis of acetylcholine (ACh) in the brain. For this purpose, the changes
THE EFFECT OF HYPOXIA ON MONOAMINE SYNTHESIS, LEVELS AND METABOLISM IN RAT BRAIN
TLDR
The dercreased synthesis and metabolism of the monoamines is most likely attributable to insufficient brain tissue oxygen as a substrate for the two hydroxylase enzymes.
Effect of Decreased Oxygen on In Vitro Release of Endogenous 3,4‐Dihydroxyphenylethylamine from Mouse Striatum
TLDR
Regardless of exogenous DA, hypoxia and anoxia increased extracellular DA, which may play a role in ischemic cell damage, and the amount of DA added to the media was critical; in the presence of high concentrations of DA, anoxial reduced reuptake.
Differential effects of hypoxia on the turnover of norepinephrine and epinephrine in the heart, adrenal gland, submaxillary gland and stomach.
TLDR
The results show that the effects of hypoxia on the activities of the sympathoadrenal system differ depending on the organs; activities are increased in the heart and adrenal gland, decreased in the submaxillary gland and unchanged in the stomach.
Neurotransmitter Metabolism in Rat Brain Synaptosomes: Effect of Anoxia and pH
TLDR
Responses of synaptosomes to anaerobiosis are remarkably similar to the behavior of intact brain in hypoxia and ischemia, and neurotransmitter uptake systems are more sensitive to short periods of anaerOBiosis than are either the energy metabolism or ion transport.
Enhancement of Dopamine Release In Vivo from the Rat Striatum by Dialytic Perfusion of 6R‐l‐erythro‐5,6,7,8‐Tetrahydrobiopterin
TLDR
The results suggest that 6R‐BH4 has a dopamine‐releasing action, which is not dependent on biosynthesis of dopamine.
Enhancement of In Vivo Tyrosine Hydroxylation in the Rat Adrenal Gland Under Hypoxic Conditions
TLDR
In vivo tyrosine hydroxylation is enhanced under hypoxia, although availability of oxygen is reduced, and this enhancement is the result of both an increase in tyosine content coupled with increased sensitivity of TH to changes in tyOSine tissue content and of an increased in dependence of TH on tyrosines levels.
...
...