Effects of Hydrophilic Cyclodextrins on Aggregation of Recombinant Human Growth Hormone

@article{Tavornvipas2004EffectsOH,
  title={Effects of Hydrophilic Cyclodextrins on Aggregation of Recombinant Human Growth Hormone},
  author={Sumitra Tavornvipas and Shinichiro Tajiri and Fumitoshi Hirayama and Hidetoshi Arima and Kaneto Uekama},
  journal={Pharmaceutical Research},
  year={2004},
  volume={21},
  pages={2369-2376}
}
To evaluate the effect of hydrophilic cyclodextrins (CyDs) on the aggregation induced by different stresses and on the oxidation and deamidation of recombinant human growth hormone (rhGH). The aggregation of rhGH was induced by three denaturing techniques including chemical (4.5 M guanidine hydrochloride), thermal (differential scanning calorimetry), and interfacial denaturation (vortex agitation). The aggregates were characterized and quantified by UV spectrophotometry and size exclusion… CONTINUE READING
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