Effects of Hura crepitans and its active ingredient, daphne factor F3, on dihydrotestosterone-induced neurotrophin-4 activation and hair retardation.

@article{Uchiyama2012EffectsOH,
  title={Effects of Hura crepitans and its active ingredient, daphne factor F3, on dihydrotestosterone-induced neurotrophin-4 activation and hair retardation.},
  author={Chiyoko Uchiyama and Kazuhiro Ishida and Takuya Tsutsui and Atsushi Naito and Kei Kurita and Hiroyuki Hanihara and Tetsushi Serizawa and Masami Fujiwara and Motoyasu Ohdera},
  journal={Biological \& pharmaceutical bulletin},
  year={2012},
  volume={35 1},
  pages={
          42-7
        }
}
Neurotrophin (NT)-4 is known to be an inducer of catagen in the hair cycle, but little is known of its role in the pathogenesis of androgenetic alopecia (AGA). We previously studied the gene expression of dermal papilla cells from AGA patients and controls and found that NT-4 was up-regulated in the AGA patients. In the present study, the etiological relationship between NT-4 and androgen, which is one of the causes of AGA, and the effect of an NT-4 inhibitor on hair growth were investigated… 
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It is explored if publications, travel reports, diaries or correspondence of the botanical explorers of the 19th and early 20th centuries may serve a source of ethnopharmacological information as well and may be able to guide modern phytopharmacology research.
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References

SHOWING 1-10 OF 36 REFERENCES
Dihydrotestosterone-inducible dickkopf 1 from balding dermal papilla cells causes apoptosis in follicular keratinocytes.
TLDR
It is found that dickkopf 1 (DKK-1) is one of the most upregulated genes in balding DP cells and the data strongly suggest that DHT-inducible DKK- 1 is involved in D HT-driven balding.
Role of TGF-β2 in the human hair cycle
A new role for neurotrophin-3: involvement in the regulation of hair follicle regression (catagen).
Different gene expression profile observed in dermal papilla cells related to androgenic alopecia by DNA macroarray analysis.
A new role for neurotrophins: involvement of brain‐derived neurotrophic factor and neurotrophin‐4 in hair cycle control
TLDR
The data suggest that BDNF and NT‐4 play a previously unrecognized role in skin physiology as agents of hair growth control and TrkB agonists and antagonists deserve exploration as novel hair growth‐modulatory drugs for the management of common hair growth disorders.
Neurotrophins and their role in pathogenesis of alopecia areata.
  • V. Botchkarev
  • Biology, Medicine
    The journal of investigative dermatology. Symposium proceedings
  • 2003
TLDR
The role of neurotrophins in the pathogenesis of alopecia areata, an autoimmune disorder that affects actively growing hair follicles, and their agonists/antagonists is focused on.
Neurogenic inflammation in stress-induced termination of murine hair growth is promoted by nerve growth factor.
Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity
TLDR
It is concluded that abnormal expansion of polyQ may potentiate innate androgens-dependent association of AR with Rb, which appears to lead to androgen-dependent onset of SBMA through aberrant E2F transactivation caused by suppressed histone deacetylation.
A role for p75 neurotrophin receptor in the control of apoptosis‐driven hair follicle regression
TLDR
Findings suggest that p75NTR signaling is involved in the control of kerotinocyte apoptosis during catagen and that pharmacological manipulation of p75 NTR signaling may prove useful for the treatment of hair disorders that display premature entry into catagen.
Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammatory events via neuropeptide substance P-dependent pathways.
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