Effects of High-cholesterol Diet on Pravastatin Disposition in the Perfused Rat Liver

Abstract

Various nutrients modulate the expression of transporters; however, the effect of a high-cholesterol (HC) diet on the expression and function of hepatic transporters remains unclear. Here, we examined the effects of an HC diet on drug disposition via hepatic transporters, including organic anion-transporting polypeptide (Oatp), multidrug resistance… (More)
DOI: 10.1007/s13318-016-0367-9

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