Effects of High-Temperature-Pressure Polymerized Resin-Infiltrated Ceramic Networks on Oral Stem Cells

  title={Effects of High-Temperature-Pressure Polymerized Resin-Infiltrated Ceramic Networks on Oral Stem Cells},
  author={Mathilde Tassin and E. Bont{\'e} and L. Loison-Robert and Ali Nassif and T. Berbar and S. Le Goff and A. Berdal and M. Sadoun and B. Fournier},
  journal={PLoS ONE},
Objectives The development of CAD—CAM techniques called for new materials suited to this technique and offering a safe and sustainable clinical implementation. The infiltration of resin in a ceramic network under high pressure and high temperature defines a new class of hybrid materials, namely polymer infiltrated ceramics network (PICN), for this purpose which requires to be evaluated biologically. We used oral stem cells (gingival and pulpal) as an in vitro experimental model. Methods Four… Expand
Biocompatibility of polymer-infiltrated-ceramic-network (PICN) materials with Human Gingival Keratinocytes (HGKs).
Promising results could notably be explained by PICN high temperature-high pressure (HT-HP) innovative polymerization mode, as confirmed by the absence of monomer release and indirect cytotoxicity. Expand
Human Gingival Epithelial Growth In Vitro on a Polymer-Infiltrated Ceramic Network Restorative Material.
PICN material polished to a smooth surface (Ra < 0.254 μm) resulted in exponential growth of HGE cell growth compared to rough surfaces, contrary to previous research regarding surface roughness of transgingival implant restoration components. Expand
Biomechanical properties of polymer-infiltrated ceramic crowns on one-piece zirconia implants after long-term chewing simulation
PICN on one-piece zirconia implants showed high bond strength and high wear after long-term chewing simulation (CS), and was mostly located in the crowns, not on the implants. Expand
Response of two gingival cell lines to CAD/CAM composite blocks.
HGF cell proliferation was higher than HGK with almost all investigated materials and at all time points, and HGK proliferation and cytotoxicity appeared to be more influenced by composite materials compared to HGF, demonstrating EN cytotoxic effects in HGK. Expand
Influence of polymerization pressure and post-cure treatment on conversion degree and viscoelastic properties of polymer infiltrated ceramic network.
It is suggested that 100-150 MPa without PC is an optimum polymerization parameter, resulting in PICN blocks with significantly better DC, Tg, E' and Tg. Expand
Dental Pulp Stem Cells: What’s New?
Since the discovery of dental pulp stem cells at the beginning of this century, there has been a rapid escalation of published reports describing the different stem/progenitor cells types derivedExpand
In Vitro Analysis of the Cytotoxicity of Indirect Restorative Materials.
A simulation of the removal of toxic components by biological fluids, conducted by using longer extraction times and daily washing, led to the absence of cytotoxicity in all the tested restorative materials. Expand
Le réseau céramique infiltré de polymères, revue de littérature
La Conception et la Fabrication Assistees par Ordinateur (CFAO) a ete introduite en odontologie au debut des annees 1980. Du fait de la demande croissante en esthetique et en degre de precision, lesExpand
Fracture toughness, flexural strength and flexural modulus of new resin-composite CAD/CAM blocks
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High-temperature-pressure Polymerized Resin-infiltrated Ceramic Networks
The results suggested that RIGCN and HT/HP polymerization could be used to obtain CB with superior mechanical properties, suitable for CAD/CAM applications. Expand
A novel polymer infiltrated ceramic dental material.
  • Li-hong He, M. Swain
  • Materials Science, Medicine
  • Dental materials : official publication of the Academy of Dental Materials
  • 2011
The polymer infiltrated ceramic material is anticipated to become a new member of the dental CAD/CAM family and illustrates a significant indentation size effect for elastic modulus and hardness, and has similar indentation creep behavior to human enamel. Expand
Immediate and late analysis of dental pulp stem cells viability after indirect exposition to alternative in-office bleaching strategies
Proposals for in-office dental bleaching to be performed with limited aggressive effect on dental pulp stem cells are presented, able to offer interesting clinical alternatives for bleaching vital teeth, under professional supervision, maintaining the integrity and reparative capacity of pulp-dentin complex. Expand
Elution of monomers from two conventional dental composite materials.
The 40s that are usually used for the polymerization of resin composites seems insufficient in order to prevent a high release of monomers after polymerization, as shown in the results of this study. Expand
Properties of experimental urethane dimethacrylate-based dental resin composite blocks obtained via thermo-polymerization under high pressure.
The results of this study suggested that RCB suitable for dental CAD/CAM applications could be obtained by HP/HT polymerization of resin composites based on pure UDMA. Expand
Cytotoxicity of dental composites and their leached components.
The cytotoxicity level of resin-based dental composites depends on their chemical composition, leaching medium, and the amount and type of the components that can be extracted from the materials. Expand
SEM evaluation of human gingival fibroblasts growth onto CAD/CAM zirconia and veneering ceramic for zirconia.
Results showed a better adhesion and cell growth in Group A than in Group B, especially up to 72h in vitro, probably because of the rougher surface of CAD/CAM zirconia, promoting better cell adhesion, compared to the smoother surface of veneering ceramic. Expand
The effect of dental restorative materials on dental biofilm.
It is indicated that amalgam, gold, compomer and glass-ionomer cement exert an influence against the adhering biofilm. Expand
Chemical Softening and Wear of Dental Composites
The purpose of this work was to determine the influence of chemical food-simulating liquids on the wear of various commercial dental composite restoratives and found that the increase in wear rate from pre-conditioning corresponded to the fall in hardness. Expand
Characterization of a polymer-infiltrated ceramic-network material.
The PICN material showed mechanical properties between porcelains and resin-based composites, reflecting its microstructural components, including ceramic- and a polymer-based interpenetrating network. Expand