Effects of High-Dose Methadone Maintenance on Cocaine Place Conditioning, Cocaine Self-Administration, and Mu-Opioid Receptor mRNA Expression in the Rat Brain

Abstract

Methadone maintenance at appropriate doses can effectively reduce cocaine abuse in heroin-dependent individuals. In the present studies, we investigated the effect of high-dose methadone maintenance cocaine conditioned place preference (CPP) and cocaine intravenous self-administration. Rats implanted with methadone-filled osmotic mini-pumps (20 and 55 mg/kg… (More)
DOI: 10.1038/sj.npp.1300927

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@article{Leri2006EffectsOH, title={Effects of High-Dose Methadone Maintenance on Cocaine Place Conditioning, Cocaine Self-Administration, and Mu-Opioid Receptor mRNA Expression in the Rat Brain}, author={Francesco Leri and Yan Zhou and Benjamin Goddard and Erin N Cummins and Mary Jeanne Kreek}, journal={Neuropsychopharmacology}, year={2006}, volume={31}, pages={1462-1474} }