Effects of Hesperidin on H2O2-Treated Chondrocytes and Cartilage in a Rat Osteoarthritis Model

@article{Gao2018EffectsOH,
  title={Effects of Hesperidin on H2O2-Treated Chondrocytes and Cartilage in a Rat Osteoarthritis Model},
  author={Gongming Gao and H. Ding and C. Zhuang and Weimin Fan},
  journal={Medical Science Monitor : International Medical Journal of Experimental and Clinical Research},
  year={2018},
  volume={24},
  pages={9177 - 9186}
}
  • Gongming Gao, H. Ding, +1 author Weimin Fan
  • Published 2018
  • Chemistry, Medicine
  • Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background The purpose of this research was to investigate the effects of hesperidin on hydrogen peroxide (H2O2)-induced chondrocytes injury and cartilage degeneration in a rat model of osteoarthritis (OA). Material/Methods Chondrocytes were isolated from rat knee joints and treated with hesperidin alone or combined with H2O2. Then, Cell Counting Kit-8 (CCK-8) assay was used to assess cell viability. Activity of reactive oxygen species (ROS) and levels of malondialdehyde (MDA) were estimated… Expand
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