Effects of Herceptin treatment on global gene expression patterns in HER2-amplified and nonamplified breast cancer cell lines

@article{Kauraniemi2004EffectsOH,
  title={Effects of Herceptin treatment on global gene expression patterns in HER2-amplified and nonamplified breast cancer cell lines},
  author={P{\"a}ivikki Kauraniemi and Sampsa Hautaniemi and Reija Autio and Jaakko Astola and Outi Monni and Abdel G. Elkahloun and Anne Kallioniemi},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={1010-1013}
}
Herceptin is a humanized monoclonal antibody targeted against the extracellular domain of the HER2 oncogene, which is amplified and overexpressed in 10–34% of breast cancers. Herceptin therapy provides effective treatment in HER2-positive metastatic breast cancer, although a favorable treatment response is not achieved in all cases. Here, we show that Herceptin treatment induces a dose-dependent growth reduction in breast cancer cell lines with HER2 amplification, whereas nonamplified cell… CONTINUE READING

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