Effects of Helicobacter pylori CagA protein on the growth and survival of B lymphocytes, the origin of MALT lymphoma

@article{Umehara2003EffectsOH,
  title={Effects of Helicobacter pylori CagA protein on the growth and survival of B lymphocytes, the origin of MALT lymphoma},
  author={Shintaro Umehara and Hideaki Higashi and Naomi Ohnishi and Masahiro Asaka and Masanori Hatakeyama},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={8337-8342}
}
Helicobacter pylori (H. pylori) is a causative agent of gastrointestinal diseases such as atrophic gastritis and gastroduodenal ulcer. Infection of cagA-positive H. pylori is also associated with gastric carcinoma and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. The cagA gene product CagA is directly injected into the bacteria-attached host cells via the bacterial type IV secretion system. The translocated CagA deregulates intracellular signaling pathways and thereby initiates… CONTINUE READING
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