Effects of HMG-CoA reductase inhibitors on growth and differentiation of cultured rat skeletal muscle cells.

@article{Veerkamp1996EffectsOH,
  title={Effects of HMG-CoA reductase inhibitors on growth and differentiation of cultured rat skeletal muscle cells.},
  author={Jacques H. Veerkamp and Johan W. Smit and Ad A. G. M. Benders and Arie Oosterhof},
  journal={Biochimica et biophysica acta},
  year={1996},
  volume={1315 3},
  pages={217-22}
}
HMG-CoA reductase inhibitors have been associated with skeletal muscle myopathy, ranging from asymptomatic elevations of serum creatine kinase (CK) activity to rhabdomyolysis. In this study, we assessed the effects of addition of different concentrations of simvastatin and pravastatin on growth and differentiation of cultured primary rat skeletal muscle cells. Protein concentrations, CK activity and percentage CK-MM, which is a parameter for maturation, were determined. Effects were generally… CONTINUE READING

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