Effects of HL-60 cell membrane glycosaminoglycans on binding of differentiation-associated receptors.

Reductions in glycosaminoglycan(s) (GAGs) have been reported during the process of leukemia cell differentiation. It has been suggested that GAG depletion may facilitate critical membrane interactions, perhaps by exposing membrane receptors to differentiation inducers. We have investigated the effects of enzymatic removal of HL-60 cell surface GAG on… CONTINUE READING