Effects of HIV-1 reverse transcriptase connection subdomain mutations on polypurine tract removal and initiation of (+)-strand DNA synthesis

Abstract

HIV-1 reverse transcriptase (RT) connection subdomain mutations at positions 348, 369 and 376 have been associated with resistance to non-nucleoside RT inhibitors (NNRTIs). N348I may interfere with the initiation of (+)-strand DNA synthesis by reducing polypurine tract (PPT) removal in the presence of nevirapine. The effect of NNRTIs on the RNase H-mediated… (More)
DOI: 10.1093/nar/gkv077

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@inproceedings{Betancor2015EffectsOH, title={Effects of HIV-1 reverse transcriptase connection subdomain mutations on polypurine tract removal and initiation of (+)-strand DNA synthesis}, author={Gilberto Betancor and Mar Alvarez and Barbara Marcelli and Cristina Llobell Andr{\'e}s and Miguel {\'A}ngel Mart{\'i}nez and L. Menendez-Arias}, booktitle={Nucleic acids research}, year={2015} }