Effects of HEMA on type I collagen protein in human gingival fibroblasts

  title={Effects of HEMA on type I collagen protein in human gingival fibroblasts},
  author={Mirella Falconi and Gabriella Teti and Michela Zago and Susi Pelotti and Lorenzo Breschi and Giovanni Mazzotti},
  journal={Cell Biology and Toxicology},
The cytotoxicity of dental composites has been attributed to the release of residual monomers from polymerized adhesive systems due to degradation processes or the incomplete polymerization of materials. 2-Hydroxyethyl methacrylate (HEMA) is one of the major components released from dental adhesives. Cytotoxic effects due to high concentrations of HEMA have already been investigated, but the influence of minor toxic concentrations on specific proteins such as type I collagen has not been… CONTINUE READING


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