Effects of H1‐antagonists on discriminative stimulus effects of cocaine and methamphetamine in rats

@article{Suzuki1996EffectsOH,
  title={Effects of H1‐antagonists on discriminative stimulus effects of cocaine and methamphetamine in rats},
  author={Tsutomu Suzuki and T. Mori and Kazuaki Takamori and Kenji Onodera and Miwa Misawa},
  journal={Behavioural Pharmacology},
  year={1996},
  volume={7},
  pages={111–118}
}
The effects of H1-antagonists, such as tripelennamine, chlorpheniramine and pyrilamine, on the discriminative stimulus effects of cocaine and methamphetamine in rats were examined. Rats were trained to discriminate between cocaine (10 mg/kg, Lp.) or methamphetamine (1.0 mg/kg, Lp.) and saline, with responses maintained under a fixed-ratio 10 (FR10) schedule of food delivery. In generalization tests, tripelennamine generalized to the discriminative stimulus effects of cocaine and methamphetamine… Expand
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