Effects of Graft Quality on Non-Urgent Liver Retransplantation Survival: Should We Avoid High-Risk Donors?

@article{Mart2012EffectsOG,
  title={Effects of Graft Quality on Non-Urgent Liver Retransplantation Survival: Should We Avoid High-Risk Donors?},
  author={Josep Mart{\'i} and Josep Fuster and Miquel Navasa and Joana Ferrer and Antoni Rimola and Amalia Pelegrina and Constantino Fondevila and Juan Carlos Garc{\'i}a‐Valdecasas},
  journal={World Journal of Surgery},
  year={2012},
  volume={36},
  pages={2914-2922}
}
BackgroundFew studies have studied the effects of graft quality on non-urgent liver retransplantation (ReLT) outcomes. We aimed to analyze graft characteristics and survival in non-urgent ReLT and the effect of using grafts with extended criteria on survival.MethodsEighty non-urgent ReLT were performed from June 1988 to June 2010. The whole series was divided by identical time periods to study time-related effects. We assessed graft quality with donor risk index (DRI) and Briceño scores and… 

Effects of Donor Age and Cold Ischemia on Liver Transplantation Outcomes According to the Severity of Recipient Status

The negative effects of prolonged CIT seem to be limited to patients with moderate MELD receiving organs procured from older donors and to high-MELD recipients, irrespective of donor age.

Extended-criteria donors in liver transplantation Part II: reviewing the impact of extended-criteria donors on the complications and outcomes of liver transplantation

Graft survival was excellent up to a DS of 2, however a DS >2 should be avoided in higher-risk recipients, andHypothermic oxygenated machine perfusion can be applied clinically in DCD liver grafts, and Feasibility and safety were confirmed.

Retransplantations in the Hungarian liver transplant program.

The donor risk index: A decade of experience

  • Avegail FloresS. Asrani
  • Medicine
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • 2017
The donor risk index (DRI) remains relevant but may benefit from being updated to provide guidance in the use of extended criteria donors by accounting for the impact of geography and unmeasured donor characteristics.

Hepatic retransplant: what have we learned?

Transplants for non-lethal conditions: a case against hand transplantation in minors

It is argued that children should not be considered for hand transplantation surgery due to the substantial risks of immunosuppressive medication, the likelihood that the graft will need to be replaced during the patient’s lifetime and the lack of significant compensatory advantages over modern prosthetics.

Liver Retransplantation: How Much Is Too Much?

References

SHOWING 1-10 OF 23 REFERENCES

Optimization of liver grafts in liver retransplantation: a European single-center experience.

Decision for Retransplantation of the Liver: An Experience- and Cost-Based Analysis

The utility of retransplantation in the elective situation is confirmed and should be used with discretion in the emergency setting, and it should be avoided in subgroups of patients with little chance of success.

Long-term survival after retransplantation of the liver.

Hematic retransplantation, although life-saving in almost 50% of patients with a failing liver allograft, is costly and uses scarce donor organs inefficiently and should assist in the rational application of retransplplantation.

Donor Factors Predicting Recipient Survival After Liver Retransplantation: The Retransplant Donor Risk Index

The ReTxDRI was predictive of overall recipient survival and was a strongly independent predictor of death after retransplantation and can improve recipient and donor matching and help to optimize posttransplant survival in liver retrans transplantation.

Use of Extended Criteria Livers Decreases Wait Time for Liver Transplantation Without Adversely Impacting Posttransplant Survival

Liver grafts from ECD can be used to dramatically reduce wait list time with outcomes comparable to those for SD without resorting to living donor liver transplantation.

A proposal for scoring marginal liver grafts

The use of marginal liver donors with more than three risk factors must be carefully reviewed or refused because of the cumulative dysfunction of these grafts.

A model to predict survival following liver retransplantation

A model that uses five readily accessible “bedside” variables to accurately predict survival in patients undergoing liver retransplantation is developed and validated and underscores the applicability of the model as an adjunct to clinical judgment.

Changing faces of liver retransplantation: It is all about selection

  • R. Ghobrial
  • Medicine
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • 2007
Changing trends of retransplantation are examined and the determination of the variables that predict re-OLT outcomes are determined, illustrating a decline in complication rates and that infection remains the most important cause of death following re- OLT.

When shouldn't we retransplant?

  • M. ZimmermanR. Ghobrial
  • Medicine
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • 2005
Re‐OLT should not be undertaken with extended and older donors particularly when retransplantation for recurrent disease is considered, and prognostic models that take into account the severity of disease and the effect of the organ to be transplanted should be developed to better predict outcomes after re‐ OLT.

Model for end-stage liver disease (MELD) and allocation of donor livers.

Data suggest that the MELD score is able to accurately predict 3-month mortality among patients with chronic liver disease on the liver waiting list and can be applied for allocation of donor livers.