Effects of Ginkgo biloba extract on the cochlear damage induced by local gentamicin installation in guinea pigs.

@article{Jung1998EffectsOG,
  title={Effects of Ginkgo biloba extract on the cochlear damage induced by local gentamicin installation in guinea pigs.},
  author={H. W. Jung and S O Chang and C. S. Kim and Chung Sik Rhee and Dong Hoon Lim},
  journal={Journal of Korean Medical Science},
  year={1998},
  volume={13},
  pages={525 - 528}
}
Investigations evaluating the protective effect of Ginkgo biloba extract (EGb) on gentamicin (GM) ototoxicity were undertaken. Guinea pigs treated with 5 mg/kg gentamicin sulfate on the round window niche (RWN) showed acute changes on electrocochleogram and hair cell or microvilli damage on scanning electron microscopy (SEM). There was accumulation of GM in the whole cochlea, especially in the organ of Corti, stria vascularis, and type III fibrocyte on immunohistochemical study. However, the… Expand
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