Effects of Ginkgo biloba extract on the pharmacokinetics and pharmacodynamics of tolbutamide in protein-restricted rats.

@article{Taki2011EffectsOG,
  title={Effects of Ginkgo biloba extract on the pharmacokinetics and pharmacodynamics of tolbutamide in protein-restricted rats.},
  author={Yuko Taki and Eri Hagiwara and Chiemi Hirose and Kazumasa Shinozuka and Keizo Umegaki and Shizuo Yamada},
  journal={The Journal of pharmacy and pharmacology},
  year={2011},
  volume={63 9},
  pages={1238-43}
}
OBJECTIVES Effects of repeated administration of Ginkgo biloba extract on pharmacokinetics and pharmacodynamics of tolbutamide were examined in rats fed a low-protein diet. METHODS   Rats were given a low (7% casein) or control (20% casein) protein diet for 21 days and administered Ginkgo biloba extract (100mg/kg per day) for the last 5 days. Tolbutamide was co-administered on the last day. Blood glucose and plasma tolbutamide concentrations were determined over the subsequent 12h and the… CONTINUE READING

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An update on drug interactions with the herbal medicine Ginkgo biloba

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1 Excerpt

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