Effects of Ginkgo biloba extract on heart and liver mitochondrial functions: mechanism(s) of action

  title={Effects of Ginkgo biloba extract on heart and liver mitochondrial functions: mechanism(s) of action},
  author={G. Baliūtytė and R. Banienė and S. Trumbeckaitė and V. Borutaite and A. Toleikis},
  journal={Journal of Bioenergetics and Biomembranes},
  • G. Baliūtytė, R. Banienė, +2 authors A. Toleikis
  • Published 2010
  • Biology, Medicine
  • Journal of Bioenergetics and Biomembranes
  • Though extracts of Ginkgo biloba leaves (GBE) have a wide pharmacological application, little is known about GBE effects on mitochondria. In this work, effects of ethanolic GBE on the respiration of isolated rat heart and liver mitochondria were investigated. We found that GBE stimulates the pyruvate + malate-dependent State 2 respiration of heart mitochondria and decreases mitochondrial membrane potential. Uncoupling effect of GBE was found to be due to its protonophoric action and is likely… CONTINUE READING
    Influence of Ethanol Extract of Ginkgo biloba Leaves on the Isolated Rat Heart Work and Mitochondria Functions
    • 7


    Publications referenced by this paper.
    Determination of serum proteins by means of the biuret reaction.
    • 13,086
    • Open Access
    The role of mitochondria in protection of the heart by preconditioning
    • 358
    • Open Access
    The interaction of flavonoids with mitochondria: effects on energetic processes.
    • 126
    • Highly Influential
    • Open Access
    Permeabilized cell and skinned fiber techniques in studies of mitochondrial function in vivo
    • 388
    The effect of flavonoids on rat heart mitochondrial function.
    • 86
    Mitochondrial matrix reactive oxygen species production is very sensitive to mild uncoupling.
    • 238
    • Open Access