Effects of Ginkgo biloba extract on heart and liver mitochondrial functions: mechanism(s) of action

@article{Balityt2010EffectsOG,
  title={Effects of Ginkgo biloba extract on heart and liver mitochondrial functions: mechanism(s) of action},
  author={G. Baliūtytė and R. Banienė and S. Trumbeckaitė and V. Borutaite and A. Toleikis},
  journal={Journal of Bioenergetics and Biomembranes},
  year={2010},
  volume={42},
  pages={165-172}
}
  • G. Baliūtytė, R. Banienė, +2 authors A. Toleikis
  • Published 2010
  • Biology, Medicine
  • Journal of Bioenergetics and Biomembranes
  • Though extracts of Ginkgo biloba leaves (GBE) have a wide pharmacological application, little is known about GBE effects on mitochondria. In this work, effects of ethanolic GBE on the respiration of isolated rat heart and liver mitochondria were investigated. We found that GBE stimulates the pyruvate + malate-dependent State 2 respiration of heart mitochondria and decreases mitochondrial membrane potential. Uncoupling effect of GBE was found to be due to its protonophoric action and is likely… CONTINUE READING
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