Corpus ID: 1273571

Effects of Ginkgo biloba extract and tanshinone on cytochrome P-450 isozymes and glutathione transferase in rats.

@article{Yang2003EffectsOG,
  title={Effects of Ginkgo biloba extract and tanshinone on cytochrome P-450 isozymes and glutathione transferase in rats.},
  author={Xiu-fen Yang and N. Wang and W. Lu and F. Zeng},
  journal={Acta pharmacologica Sinica},
  year={2003},
  volume={24 10},
  pages={
          1033-8
        }
}
  • Xiu-fen Yang, N. Wang, +1 author F. Zeng
  • Published 2003
  • Chemistry, Medicine
  • Acta pharmacologica Sinica
  • AIM To investigate the effects of Ginkgo biloba extract (GbE) and tanshinone (Tan) on cytochrome P450 (CYP) isozymes and glutathione transferase (GT) in rats. METHODS Several CYP-dependent reactions were monitored in liver and kidney microsomes of male rats treated ig with GbE and Tan daily for 10 d. The activity of GT, the levels of malondialdehyde (MDA) and nitric oxide (NO) in the tissues were also determined. RESULTS CYP1A1, 1A2, and 2B1 activities in the liver were all significantly… CONTINUE READING
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