Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced release of nitric oxide.

@article{Wadsworth2001EffectsOG,
  title={Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced release of nitric oxide.},
  author={Teri L. Wadsworth and Dennis R. Koop},
  journal={Chemico-biological interactions},
  year={2001},
  volume={137 1},
  pages={
          43-58
        }
}
Preventive effect of Ginkgo biloba extract (GBB) on the lipopolysaccharide-induced expressions of inducible nitric oxide synthase and cyclooxygenase-2 via suppression of nuclear factor-kappaB in RAW 264.7 cells.
TLDR
GBB inhibits LPS-induced iNOS, COX-2 and TNF-alpha expressions through the down-regulation of NF-kappaB-DNA binding activity, suggesting that GBB is a more potent inhibitor of NO and PGE2 production than EGb 761.
Inhibition of nitric oxide production from lipopolysaccharide-treated RAW 264.7 cells by synthetic flavones: Structure-activity relationship and action mechanism
TLDR
Of these flavonoids that were evaluated, 2′,3′,5,7-tet-rahydroxyflavone and 3′,4′, 5,7 -tetrahydroxflav one (luteolin) showed the strongest inhibition and may have a potential as new anti-inflammatory agents.
Homocysteine stimulates inducible nitric oxide synthase expression in macrophages: Antagonizing effect of ginkgolides and bilobalide
TLDR
It is demonstrated that homocysteine, at pathophysiological concentrations, stimulates iNOS-mediated NO production in macrophages and EGb and its terpenoids can antagonize such stimulatory effect via antioxidation and attenuation of NF-κB activation.
Effects of Indole-3-Carbinol and Flavonoids Administered Separately and in Combination on Nitric Oxide Production and iNOS Expression in Rats
TLDR
The results suggest that modifications of NO level in tissues by a natural compound cannot be predicted from data about its effects on NOS expression or activity, and stresses importance of direct measurements of NO in the tissues.
Cedrela sinensis Leaves Suppress Oxidative Stress and Expressions of iNOS and COX-2 via MAPK Signaling Pathways in RAW 264.7 Cells
TLDR
The data suggest that leaves of C. sinensis could be used as a potential source for anti-inflammatory agents.
Luteolin and luteolin-7-O-glucoside from dandelion flower suppress iNOS and COX-2 in RAW264.7 cells
  • Chun HuD. Kitts
  • Chemistry, Medicine
    Molecular and Cellular Biochemistry
  • 2004
TLDR
Luteolin and luteolin-7-O-glucoside at concentrations lower than 20 μM, significantly suppressed the productions of nitric oxide and prostaglandin E2 in bacterial lipopolysaccharide activated-mouse macrophage RAW264.7 cells without introducing cytotoxicity.
Dandelion (Taraxacum officinale) flower extract suppresses both reactive oxygen species and nitric oxide and prevents lipid oxidation in vitro.
  • C. HuD. Kitts
  • Chemistry, Medicine
    Phytomedicine : international journal of phytotherapy and phytopharmacology
  • 2005
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