Effects of Ginkgo biloba Extract EGb 761, Donepezil and their Combination on Central Cholinergic Function in Aged Rats.

@article{Stein2015EffectsOG,
  title={Effects of Ginkgo biloba Extract EGb 761, Donepezil and their Combination on Central Cholinergic Function in Aged Rats.},
  author={C. Stein and Julia Hopfeld and Helene Lau and J. Klein},
  journal={Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques},
  year={2015},
  volume={18 4},
  pages={
          634-46
        }
}
  • C. Stein, Julia Hopfeld, +1 author J. Klein
  • Published 2015
  • Medicine
  • Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
  • PURPOSE Ginkgo extract EGb 761 and cholinesterase inhibitors have been shown to be effective in the treatment of dementia patients. [...] Key MethodMETHODS 24 month old rats received EGb 761 (100 mg/kg/day), donepezil (1.5 mg/kg/day), the combination of both drugs or vehicle control by oral gavage for 14 days. We used microdialysis in rat hippocampus to monitor extracellular concentrations of acetylcholine (ACh), choline, glucose and lactate. Brain homogenates were prepared to measure activities of…Expand Abstract
    Advances in the Studies of Ginkgo Biloba Leaves Extract on Aging-Related Diseases
    • 30
    • Open Access

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 49 REFERENCES
    Ginkgo biloba extract (EGb 761) and CNS functions: basic studies and clinical applications.
    • 353
    • Open Access