Effects of Ginkgo Biloba Extract on Pharmacokinetics and Pharmacodynamics of Tolbutamide and Midazolam in Healthy Volunteers

@article{Uchida2006EffectsOG,
  title={Effects of Ginkgo Biloba Extract on Pharmacokinetics and Pharmacodynamics of Tolbutamide and Midazolam in Healthy Volunteers},
  author={Shinya Uchida and Hiroshi Yamada and Xiao Dong Li and Shuji Maruyama and Yuki Ohmori and Tomomi Oki and Hiroshi Watanabe and Keizo Umegaki and Kyo‐ichi Ohashi and Shizuo Yamada},
  journal={The Journal of Clinical Pharmacology},
  year={2006},
  volume={46}
}
This study was undertaken to clarify the influence of repeated oral administration of Ginkgo biloba extract (GBE) on CYP2C9 and CYP3A4. CYP2C9 probe (tolbutamide, 125 mg) and CYP3A4 probe (midazolam, 8 mg) were orally administered to 10 male healthy volunteers before and after GBE intake (360 mg/d) for 28 days, and they received 75 g glucose after the dosing of tolbutamide. Plasma drug concentrations and blood glucose levels were measured. The area under concentration versus time curve (AUC0… Expand
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TLDR
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