Effects of Ghrelin Administration on Left Ventricular Function, Exercise Capacity, and Muscle Wasting in Patients With Chronic Heart Failure

@inproceedings{NoritoshiNagaya2004EffectsOG,
  title={Effects of Ghrelin Administration on Left Ventricular Function, Exercise Capacity, and Muscle Wasting in Patients With Chronic Heart Failure},
  author={NoritoshiNagaya and JunjiMoriya and YoshioYasumura and MasaakiUematsu and FumiakiOno and WataruShimizu and KazuyukiUeno and MasafumiKitakaze and KunioMiyatake and KenjiKangawa},
  year={2004}
}
Background— Ghrelin is a novel growth hormone–releasing peptide that also induces vasodilation, inhibits sympathetic nerve activity, and stimulates feeding through growth hormone–independent mechanisms. We investigated the effects of ghrelin on left ventricular (LV) function, exercise capacity, and muscle wasting in patients with chronic heart failure (CHF). Methods and Results— Human synthetic ghrelin (2 μg/kg twice a day) was intravenously administered to 10 patients with CHF for 3 weeks… CONTINUE READING

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