Effects of Genetic Polymorphisms of CYP2D6, CYP3A5, and ABCB1 on the Steady-State Plasma Concentrations of Aripiprazole and Its Active Metabolite, Dehydroaripiprazole, in Japanese Patients With Schizophrenia

@article{Suzuki2014EffectsOG,
  title={Effects of Genetic Polymorphisms of CYP2D6, CYP3A5, and ABCB1 on the Steady-State Plasma Concentrations of Aripiprazole and Its Active Metabolite, Dehydroaripiprazole, in Japanese Patients With Schizophrenia},
  author={T. Suzuki and K. Mihara and A. Nakamura and S. Kagawa and G. Nagai and K. Nemoto and T. Kondo},
  journal={Therapeutic Drug Monitoring},
  year={2014},
  volume={36},
  pages={651–655}
}
Background: We studied the effects of various factors, including genetic polymorphisms of the cytochrome P450 (CYP) 2D6, CYP3A5, and ABCB1, age, gender, and smoking habit on the steady-state plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole, in 89 patients with schizophrenia (46 males, 43 females). Methods: All patients had been receiving fixed doses of aripiprazole for at least 2 weeks. The daily doses were 24 mg (n = 56) and 12 mg (n = 33). No other drugs… Expand
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Phenoconversion of CYP2D6 by inhibitors modifies aripiprazole exposure
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References

SHOWING 1-10 OF 32 REFERENCES
Functional Characterization of 17 CYP2D6 Allelic Variants (CYP2D6.2, 10, 14A–B, 18, 27, 36, 39, 47–51, 53–55, and 57)
The genetic determinants of the CYP3A5 polymorphism.
...
1
2
3
4
...