Effects of Genetic Mutations and Chemical Exposures on Caenorhabditis elegans Feeding: Evaluation of a Novel, High-Throughput Screening Assay

@article{Boyd2007EffectsOG,
  title={Effects of Genetic Mutations and Chemical Exposures on Caenorhabditis elegans Feeding: Evaluation of a Novel, High-Throughput Screening Assay},
  author={Windy A. Boyd and Sandra J Mcbride and Jonathan H. Freedman},
  journal={PLoS ONE},
  year={2007},
  volume={2},
  pages={18 - 22}
}
BACKGROUND Government agencies have defined a need to reduce, refine or replace current mammalian-based bioassays with testing methods that use alternative species. Invertebrate species, such as Caenorhabditis elegans, provide an attractive option because of their short life cycles, inexpensive maintenance, and high degree of evolutionary conservation with higher eukaryotes. The C. elegans pharynx is a favorable model for studying neuromuscular function, and the effects of chemicals on… CONTINUE READING

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